A study, which was initially conducted in mice diagnosed of pancreatic cancer, has suggested that the role played by the gene in case of mice, will also be prevalent for humans.
However, it has been demonstrated by the study researchers that the expression level of the gene need to high. While analyzing the case studies of patients who died of the disease much after being operated or those who died far too quickly or in cases, where the spread of the tumor was fast, were termed to patients with low level of gene.
Researcher David Tuveson illustrated that the gene is present in all of our cells, but it is missing in a few tumors. Moreover, it was briefed that the presence of the gene was known beforehand, but its role as a cancer suppressor has been highlighted by this study.
He asserted that there are few other pancreatic suppressor genes, but if this gene is not present, then the spreading of the cancer is much more prevalent and hence, patients die soon.
However, he explained that the gene expression can be exaggerated by inducing drugs known as epigenetic modulators. He demonstrated that the drugs have shown to be potential in case of patients, who have lost the gene, hence a therapy can be provided to them to recover from the disease.
He said, “These kinds of drugs have already been developed, but people haven't figured out where exactly they would be useful. We are proposing that these drugs would be useful in this subset of pancreas cancer patients”.
http://topnews.us/content/247972-pancreatic-cancer-suppressor-gene-identified
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