Who we are.

Join the fight against pancreatic cancer! The 2014 Pancreatic Cancer Research Walk is Sunday, November 2nd at Sloan's Lake Park, Denver, CO.

All the money raised goes directly to pancreatic cancer research thanks to the Lustgarten Foundation!

Monday, October 20, 2014

Meaningful Mondays!

Lustgarten Foundation's Pancreatic Cancer Fundraising Walk - Denver shared

You're not alone in the fight against pancreatic cancer!
Join Lustgarten as we fight to find a cure.

Sunday, October 19, 2014

Walk to honor those with Pancreatic Cancer

Lustgarten's Pancreatic Cancer Research Walk in Denver: 2012 Lustgarten

You can help make a difference!  Join the fight and walk for a cure!  Register today!


Pre-Registration Fee $50
Walk-In Registration Fee $60
Registration 9:00 am
Walk starts at 10:30 am

Join us on Sunday, November 2, 2014 at Sloan's Lake Park, Denver, CO. Pancreatic Cancer Research Events are a great way to increase funding for research and raise awareness for pancreatic cancer. Lustgarten Foundation Events serve as a wonderful celebration of the progress being made in the fight against this disease, and your important participation provides hope for the future.

Saturday, October 18, 2014

Now that I have been diagnosed with Pancreatic Cancer, where do I turn for information??

Information & Support Services

Web-based & Telephone

CancerCare
1-800-813-HOPE (4673)
CancerCare is a national, nonprofit organization that helps people face the many challenges of a cancer diagnosis by offering free education and support programs to help patients and loved ones understand and deal with their diagnosis, treatment options, quality-of-life concerns, and other important issues. CancerCare offers Telephone Education Workshops (TEWs), one-hour conference calls presented by experts from around the country. In addition, CancerCare offers free Telephone Support Groups for both pancreatic cancer patients and caregivers.
Pancreatic Cancer Action
Cancer Information Service
1-800-4-CANCER / 1-800-332-8615 (TYY)
CIS is a free nationwide cancer information and education network. By calling the toll-free number, cancer patients, their families, people at risk for cancer, and health professionals can receive publications, audiovisual materials (available in English and Spanish) and other information confidentially on all aspects, including treatment and clinical trials.

Cancer.Net
Cancer.Net provides timely, oncologist-approved information to help patients and families make informed health-care decisions. All content is subject to a formal peer-review process by the Cancer.Net Editorial Board, composed of more than 150 medical, surgical, radiation, and pediatric oncologists, oncology nurses, social workers, and patient advocates.

American Cancer Society
The American Cancer Society is the nationwide community-based voluntary health organization dedicated to eliminating cancer as a major health problem by preventing cancer, saving lives, and diminishing suffering from cancer, through research, education, advocacy, and service.

OncoLink.org
OncoLink, a free on-line service of the University of Pennsylvania Cancer Center, is a complete source of cancer information for patients, their families, caretakers and friends. Visitors can get information on everything from cancer support services, resources, books, to even a special section offering humor called OncoLink LITE.

CancerConnect
CancerConnect is dedicated to providing the most up-to-date information on the treatment and prevention of cancer.

CaringBridge
CaringBridge offers free, private Web sites for people facing a serious health event. Using a CaringBridge Web page, patients and caregivers can share updates, post photos, and receive messages of hope and encouragement through a guestbook.

Vital Options
1-800-477-7666
Vital Options is a telesupport cancer network and the nation's only call-in cancer radio show. It airs The Group Room, a weekly live radio show simulcast on the Web.

The Wellness Community
1-888-793-WELL
Education and support services for cancer patients and their families, including support groups, stress-reduction techniques, cancer education workshops, etc.

ACOR.org
ACOR cancer information system offers patients and their families access to electronic mailing lists and Web sites. The lists are public on-line support groups, which provide information and support to anyone seeking answers about cancer and related disorders.

Johns Hopkins Discussion Forum
This unmoderated discussion forum allows patients to post messages and communicate about pancreas cancer.

John Hopkins iCarebook for Pancreatic Cancer
The Johns Hopkins iPAD application for Pancreatic Cancer is an educational guide for patients, family members and friends facing a diagnosis of pancreatic cancer. Created by leading experts in the field, this interactive application includes text, illustrations, animations and videos. Emphasis is placed on multi-disciplinary care and the team approach.  The App is free and is available in the iTunes store.

https://itunes.apple.com/us/app/icarebook-hd/id697194060?ls=1&mt=8

For a description of the App, please go to their Website:

http://pathology.jhu.edu/pancreas/icarebook/index.php
Johns Hopkins Pancreatic Cancer Blog

Thomas Jefferson University Hosptials Ask the Experts
This forum seeks to build awareness about the condition and give patients, families and caregivers an opportunity learn more about the available treatment options.

Patient Resource Publishing
Patient Resource Publishing provides free, trusted resources to cancer patients, including a Cancer Resource Guide. PRP also manages www.MyCancerAdvisor.com, a Web site dedicated to patient advocacy and empowerment through education.  Visitors to MyCancerAdvisor can share information and connect with others in a community of learning and support.

Whipple Warriors
info@whipplewarriors.org
Whipple Warriors is a group whose mission is to educate, support and advocate for all whipple surgery survivors.

Cancer Care - A Helping Hand
The resources guide for people facing financial challenges.  Order copies of "A Helping Hand" completely free of charge today at www.cancercare.org/publications/order.  supply is limited.
Cancer Legal Resource Center
Cancer Legal Resource Center (CLRC) is a joint program of Disability Rights Legal Center and Loyola Law School, Los Angeles. The CLRC provides information and education about cancer-related legal issues to the public through its national telephone assistance line.

Support Groups & Health Fairs

- Telephone Education Workshop

View Webcast of Medical Update on the Treatment of Pancreatic Cancer
Presented by CancerCare

Ongoing - Community Support Groups

Wellness Centers*

*Supported by the Michael Rolfe Pancreatic Cancer Foundation
Cancer Wellness Center
215 Revere Drive
Northbrook, IL 60062
Phone: 847-509-9595 or 866-292-9355 (toll-free)
Pancreatic Cancer Networking Group meets 2nd Thursday of the month (6:45 – 8:30 p.m.)
Wellness House
131 N. County Line Road
Hinsdale, IL 60521
Phone: 630-323-5150
Pancreatic Cancer Networking Drop-in Group meets 4th Tuesday of the month (7 – 9 p.m.)
Jennifer S. Fallick Cancer Support Center
2028 Elm Road
Homewood, IL 60430
Phone: 708-798-9171
Pancreatic Cancer Networking Drop-in Group meets 4th Wednesday of the month (7:00 – 8:30 p.m.)

Friday, October 17, 2014

Count Me In! Fighting Pancreatic Cancer!

Has pancreatic cancer affected your family?  Do you want to help find a cure?  Then the Denver Lustgarten Pancreatic Cancer Walk need your help!  

After school volunteers neededHere's your opportunity to give to the cause with your time and energy.  Whether you're looking to join the Walk Committee or the want to be a "day of volunteer" call us! We need your help!

Click here to learn more or call Ann Walsh at 516.803.2419.



Thursday, October 16, 2014

I walk because ...


Thousands of people across the country are inspired to walk each year for a cure.  Over six years ago, Meg Phillips and her family introduced Denver to the Lustgarten Foundation by kicking off the first annual fundraising walk for pancreatic cancer.  Today, the walk has raised over $350,000 towards pancreatic cancer research.  

Wednesday, October 15, 2014

NIH scientists visualize how cancer chromosome abnormalities form in living cells

For the first time, scientists have directly observed events that lead to the formation of a chromosome abnormality that is often found in cancer cells. The abnormality, called a translocation, occurs when part of a chromosome breaks off and becomes attached to another chromosome.  The results of this study, conducted by scientists at the National Cancer Institute (NCI), part of the National Institutes of Health, appeared Aug. 9, 2013, in the journal Science.

Chromosomes are thread-like structures inside cells that carry genes and function in heredity. Human chromosomes each contain a single piece of DNA, with the genes arranged in a linear fashion along its length.

Chromosome translocations in a living cell

For the first time, scientists have directly observed events that lead to formation of a chromosome abnormality that is often found in cancer cells. The results of this study--from senior author Tom Mistelli, Ph.D., lead author Vassilis Roukos, Ph.D., and colleagues at the National Cancer Institute--appears in the Aug 9, 2013 issue of the journal Science.
Chromosome translocations have been found in almost all cancer cells, and it has long been known that translocations can play a role in cancer development. However, despite many years of research, just exactly how translocations form in a cell has remained a mystery. To better understand this process, the researchers created an experimental system in which they induced, in a controlled fashion, breaks in the DNA of different chromosomes in living cells. Using sophisticated imaging technology, they were then able to watch as the broken ends of the chromosomes were reattached correctly or incorrectly inside the cells.
Translocations are very rare events, and the scientists’ ability to visualize their occurrence in real time was made possible by recently available technology at NCI that enables investigators to observe changes in thousands of cells over long time periods. “Our ability to see this fundamental process in cancer formation was possible only because of access to revolutionary imaging technology,” said the study’s senior author, Tom Misteli, Ph.D., Laboratory of Receptor Biology and Gene Expression, Center for Cancer Research, NCI.

The scientists involved with this study were able to demonstrate that translocations can occur within hours of DNA breaks and that their formation is independent of when the breaks happen during the cell division cycle. Cells have built-in repair mechanisms that can fix most DNA breaks, but translocations occasionally occur.

To explore the role of DNA repair in translocation formation, the researchers inhibited key components of the DNA damage response machinery within cells and monitored the effects on the repair of DNA breaks and translocation formation. They found that inhibition of one component of DNA damage response machinery, a protein called DNAPK-kinase, increased the occurrence of translocations almost 10-fold. The scientists also determined that translocations formed preferentially between pre-positioned genes.
“These observations have allowed us to formulate a time and space framework for elucidating the mechanisms involved in the formation of chromosome translocations,” said Vassilis Roukos, Ph.D., NCI, and lead scientist of the study. 

“We can now finally begin to really probe how these fundamental features of cancer cells form,” Misteli added.

This research was supported by the Intramural Research Program of the NCI’s Center for Cancer Research.
###
Reference:   Roukos V, Voss TC, Schmidt CK, Lee S, Wangsa D, Misteli T. Spatial dynamics of chromosome translocations in living cells. Science. August 9, 2013. DOI: 10.1126/science.1237150.

Tuesday, October 14, 2014

Large study reveals increased cancer risks associated with family history of the disease

Public release date: 24-Jul-2013

Contact: Emma Mason
wordmason@mac.com
European Society for Medical Oncology 

Lustgarten Foundation's Pancreatic Cancer Fundraising Walk - Denver added 8A family history of cancer increases the risk of other members of the family developing not only the same cancer (known as a concordant cancer) but also a different (discordant) cancer, according to a large study of 23,000 people in Italy and Switzerland.


The research, published in the leading cancer journal Annals of Oncology [1] today (Thursday), provides a comprehensive picture of the risk of developing various different types of cancer in families where there is a history of the disease, and is one of the few large studies of this kind that takes into account other important factors, such as individual characteristics and lifestyles, that could affect the degree of risk as well.

Results from the study supported known associations, such as the increased risk of developing the same cancer as a close relative, and the 1.5-fold increased risk of breast cancer in women with a history of colorectal cancer in the family. However, the study also found a 3.3-fold increased risk of developing oral and pharyngeal cancer among people who had a first-degree relative with cancer of the larynx, and a four-fold increased risk of cancer of the gullet (oesophageal cancer) where a first-degree relative had oral or pharyngeal cancer. If a first-degree relative had breast cancer, female family members had a 2.3-fold increased risk of ovarian cancer. Family members had a 3.4-fold increased risk of prostate cancer if a first-degree relative had bladder cancer.

The researchers from Italy, Switzerland and France looked at 12,000 cases of cancer occurring in 13 different cancer sites (mouth and pharynx, nasopharynx, oesophagus, stomach, colorectum, liver, pancreas, larynx, breast, womb, ovaries, prostate and kidneys) between 1991 and 2009. They matched them with 11,000 people without cancer, and collected information on any cancer in the family, particularly in a first-degree relative, age at diagnosis, sociodemographic characteristics, body shape, lifestyle habits such as smoking and alcohol intake, diet, personal medical history, including menstrual and reproductive factors, and use of oral contraceptives and hormone replacement therapy.

Dr Eva Negri, head of the Laboratory of Epidemiologic Methods at the Mario Negri Institute for Pharmacological Research, Milan, Italy, said: "Besides confirming and quantifying the well-known excess risks of people developing the same cancer as their first-degree relative, we have identified increased risks for developing a number of different cancers. We have also found that if a patient was diagnosed with certain cancers when they were younger than 60, the risks of a discordant cancer developing in family members were greater.

"A major strength of our study is that we were able to adjust our analyses for tobacco, alcohol and a number of other lifestyle habits, which most previous studies have not been able to do."

Dr Negri said that some of the associations between discordant cancers were probably due to shared environmental factors such as family habits of smoking and drinking. However, she said: "Our results point to several potential cancer syndromes that appear among close relatives and that indicate the presence of genetic factors influencing multiple cancer sites. These findings may help researchers and clinicians to focus on the identification of additional genetic causes of selected cancers and on optimizing screening and diagnosis, particularly in people with a family history of cancer at a young age."
She said that the large numbers of patients in the study enabled the researchers to identify associations even for some rare cancers.

"For some rare cancers, a weak association with a different, common cancer can, on a population level, reveal a higher attributable risk than a strong association with the risk of developing the same cancer. For example, for ovarian cancer we found that a family history of breast cancer had a stronger attributable risk of ovarian cancer than the far rarer, albeit stronger, association with family history of ovarian cancer."
The researchers are still collecting data on the people they are studying, including biological material, which could help them to identify genetic factors that could be playing a role in the increased risk for people with a family history of cancer. They also plan to investigate whether some well-recognised risk factors are involved in increasing the risk to family members of developing concordant or discordant cancers, and if so, to what extent.
###
Notes:
[1] "Family history of cancer and the risk of cancer: a network of case-control studies", by F. Turati, V. Edefonti, C. Bosetti, M. Ferraroni, M. Malvezzi, S. Franceschi, R. Talamini, M. Montella, F. Levi, L. Dal Maso, D. Serraino, J. Polesel, E. Negri, A. Decarli, C. La Vecchia. Annals of Oncology. doi:10.1093/annonc/mdt280
[2] This study supported by the Italian Association for Cancer Research.

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