Who we are.

Join the fight against pancreatic cancer! The 2015 Pancreatic Cancer Research Walk is Sunday, November 1st at Sloan's Lake Park, Denver, CO.

All the money raised goes directly to pancreatic cancer research thanks to the Lustgarten Foundation!

Tuesday, September 25, 2012

Give us a hand.



Each year, the Pancreatic Cancer Walk in Denver is a huge success -- not just because of those who walk but because of the volunteers.  Hundreds come to the event each year just to help out and help make a difference.  If you are interested in volunteering contact Kim at kimphillips14@gmail.com to learn more.

Monday, September 24, 2012

Be a hero -- Volunteer!


Each year, the Pancreatic Cancer Walk in Denver is a huge success -- not just because of those who walk but because of the volunteers.  Hundreds come to the event each year just to help out and help make a difference.  If you are interested in volunteering contact Kim at kimphillips14@gmail.com to learn more.

Sunday, September 23, 2012

Research study reports extending survival in mice by 70 percent; initial studies in humans are under way


Dr. Sunil Hingorani
SEATTLE – March 19, 2012 – Pancreas cancer tumors spread quickly and are notoriously resistant to treatment, making them among the deadliest of malignancies. Their resistance to chemotherapy stems in part from a unique biological barrier the tumor builds around itself.  Now scientists at Fred Hutchinson Cancer Research Center have found a way to break through that defense, and their research represents a potential breakthrough in the treatment of pancreas cancer.

In a paper to be published in the March 20 issue of Cancer Cell, senior author Sunil Hingorani, M.D., Ph.D., an associate member of the Hutchinson Center’s Clinical Research and Public Health Sciences divisions, and colleagues describe the biological mechanisms of how the tumor barrier is formed and detail a newly discovered way to break it down. Their research significantly increased the length of survival in a genetically engineered mouse model of the disease. Early clinical trials in humans are under way at a few sites in the U.S. and Europe, including Seattle Cancer Care Alliance, the Hutchinson Center’s patient treatment arm.

Details about the open clinical trial can be found here: http://clinicaltrials.gov/show/NCT01453153
Using a mouse model developed by Hingorani, the scientists combined gemcitabine, the current standard chemotherapy used to treat pancreatic ductal adenocarcinomas, with an enzyme called PEGPH20. When they infused the combination into specially engineered mice whose pancreas tumors mimic those of human pancreas cancer, the combination broke down the matrix barrier within the tumors and allowed the chemotherapy to permeate freely and spread throughout the cancerous tissue. The result was a 70 percent increase in survival time of the mice after the start of treatment, from 55 to 92 days.

“This represents the largest survival increase we’ve seen in any of the studies done in a preclinical model, and it rivals the very best results reported in humans,” Hingorani said.

Unlike most solid tumors, pancreas tumors use a two-pronged defense to keep small molecules, such as those contained in chemotherapy, from entering: a vastly reduced blood supply and the creation of a strong fibroinflammatory response. The latter includes the production of fibroblasts, immune cells and endothelial cells that become embedded within a dense and complex extracellular matrix throughout the tumor. One major component of this matrix is a substance called hyaluronan, or hyaluronic acid (HA). HA is a glycosaminoglycan, a complex sugar that occurs naturally in the body and is secreted at extremely high levels by pancreas cancer cells.

Hingorani and colleagues discovered that the fibroinflammatory response creates unusually high interstitial fluid pressures that collapse the tumor’s blood vessels. This in turn prevents chemotherapy agents from entering the tumors. The researchers found that HA is the main biological cause of the elevated pressures that leads to blood vessel collapse.

“That’s the primary reason pancreas cancers are resistant to everything we’ve thrown at them: because none of the drugs get into the tumor. It’s physics first, before we even get to the intrinsic biology,” Hingorani said.
Administering the enzyme/gemcitabine combination degrades HA in the tumor barrier and results in rapid reduction of the interstitial fluid pressure. This in turn opens the blood vessels and permits high concentrations of chemotherapy to reach the tumor.

“Being able to deliver the drugs effectively into the tumor resulted in improved survival as well as the realization that pancreas cancer may be more sensitive to conventional chemotherapy than we previously thought,” Hingorani said.

Pancreatic ductal adenocarcinoma is the fourth leading cause of cancer-related death in the United States. Overall five-year survival is less than 5 percent with a median survival of four to six months.
Grants from the National Cancer Institute, the Giles W. and Elise G. Mead Foundation, Safeway and several individuals supported the research. Collaborators from the University of Washington and the Translational Genomics Research Institute in Scottsdale, Ariz., contributed to the study.

MEDIA CONTACT
Dean Forbes
206-667-2896
dforbes@fhcrc.org

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At Fred Hutchinson Cancer Research Center, our interdisciplinary teams of world-renowned scientists and humanitarians work together to prevent, diagnose and treat cancer, HIV/AIDS and other diseases. Our researchers, including three Nobel laureates, bring a relentless pursuit and passion for health, knowledge and hope to their work and to the world. For more information, please visit fhcrc.org.

Saturday, September 22, 2012

Ask an expert at The Lustgarten Foundation

Each week, pancreatic cancer patients and their families are invited to ask questions on Lustgarten's Facebook page.  Check it out because sometimes it's hard to ask a physician some of those most important questions.

Visit Lustgarten's main Facebook page ...
https://www.facebook.com/CurePancreaticCancer

Thursday, September 20, 2012

NEW PANCREATIC CANCER CLINICAL TRIAL APPLIES REVOLUTIONARY IMMUNOTHERAPY APPROACH THAT GENETICALLY MODIFIES T CELLS


The Lustgarten Foundation and the Cancer Research Institute Co-Sponsor New Study
at Perelman School of Medicine at the University of Pennsylvania to Help Immune
System Target and Eliminate Cancer Cells

BETHPAGE, NY  – August 15, 2012 – The Lustgarten Foundation, the nation’s largest private foundation
dedicated solely to funding pancreatic cancer research, and the Cancer Research Institute (CRI), a  nonprofit
organization devoted to transforming cancer patient care through the discovery and development of immune
system-based cancer therapies, are co-sponsoring a new approach to the treatment of pancreatic cancer. A new clinical trial led by Dr. Carl June and Dr. Gregory Beatty at the Perelman School of Medicine at the University of Pennsylvania will focus on altering and training a patient’s immune system to target and eliminate cancer cells.

As part of the clinical trial, each participating patient will have a type of immune cell called T cells removed from their blood. Using a revolutionary new approach, the T cells are then genetically modified to express protein complexes known as chimeric antigen receptors (CARs), which act as a tool to help the reprogrammed T cells recognize and destroy pancreatic cancer cells. The altered T cells are put back into the patient so his or her immune system can begin fighting the pancreatic cancer.

“Think of it like altering the gene sequence of these T cells so that they become trained assassins working for an individual’s immune system, focused exclusively on finding and killing the cancer cells,” said Dr. Carl June,
professor of Pathology and Laboratory  Medicine, the  Perelman School of Medicine at the University of
Pennsylvania. “This research has shown very promising results in other cancers we’ve applied it to, so we’re
grateful to The Lustgarten Foundation and the Cancer Research Institute for their support, which will enable us to continue this important work for pancreatic cancer.”

“Pancreatic cancer is the most lethal of all cancers. That’s why this new research is so promising and that’s why we’re pleased to partner with the Cancer Research Institute and the University of Pennsylvania  to conduct this clinical trial,” said Kerri Kaplan, executive director, The Lustgarten Foundation. “We remain dedicated to advancing pancreatic cancer research by funding promising studies like this one, so we can find better treatments and ultimately, a cure for pancreatic cancer.”

“We are proud to collaborate with The Lustgarten Foundation and the University of Pennsylvania on this new approach to treating pancreatic cancer with the immune system,” said Jill O’Donnell-Tormey, Ph.D., chief executive officer and director of scientific affairs, the Cancer Research Institute. “This powerful partnership leverages our combined expertise in cancer immunotherapy, pancreatic cancer, and treating cancer patients to bring new hope to people impacted by this deadly disease.”

Page 2 - New Pancreatic Cancer Clinical Trial Applies Revolutionary Immunotherapy Approach That Genetically Modifies T Cells. The collaborative study grew out of a daylong think tank organized by the Cancer Research Institute and The Lustgarten  Foundation, whereby a research map for immunotherapy for pancreatic cancer was identified and prioritized.

This trial is expected to open this fall and continue throughout the next year. About The Lustgarten Foundation The Lustgarten Foundation is America’s largest private foundation dedicated solely to funding pancreatic cancer research. Based in Bethpage, New York, the Foundation supports research to find a cure for pancreatic cancer, facilitates dialogue within the medical and scientific community, and educates the public about the disease through awareness campaigns and fundraising events. The Foundation has provided millions of research dollars and assembled the best scientific minds with the hope that one day, a cure can be found. And because Cablevision Systems Corporation, a leading media and telecommunications company, underwrites all of The Lustgarten Foundation’s administrative costs, 100 percent of every dollar donated to the Foundation goes directly to pancreatic cancer research. Learn more at www.lustgarten.org.

About the Cancer Research Institute
The Cancer Research Institute (CRI), established in 1953, is the world’s only nonprofit organization dedicated exclusively to transforming cancer patient  care by advancing scientific efforts to develop new and effective immune system-based strategies to prevent, diagnose, treat, and cure cancer. Guided by a world-renowned Scientific Advisory Council that includes three Nobel laureates and 30 members of the  National Academy of Sciences, CRI has invested more than $200 million in support of research conducted by immunologists and tumor immunologists at the world’s leading medical centers and universities, and has contributed to many of the key scientific advances that demonstrate the potential for immunotherapy to change the face of cancer treatment. Learn more at www.cancerresearch.org.

About Perelman School of Medicine at the University of Pennsylvania
The Perelman School of Medicine is currently ranked #2 in  U.S. News & World Report's survey of researchoriented medical schools and is consistently among the nation's top three recipients of federal funding from the National Institutes of Health. Penn's physicians  and scientists focus on research that utilizes an interdisciplinary approach to understand the fundamental mechanisms of disease, leading to new strategies for treatments and cures. In addition, faculty from 23 institutes and centers at Penn Medicine work together with their counterparts from the 11 other schools at the University of Pennsylvania to collaborate in such disparate areas as aging, neuroscience, and the impact of health care policy.
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Wednesday, September 19, 2012

Find Hope After Cancer Strikes


Not pancreatic cancer, but an inspiring story nonetheless.

120912melissa.JPGBy Jacob Noack

Jacob Noack created the Melissa Hunter-Noack Foundation in memory of his wife after she passed away from a pseudopapillary tumor.

After returning from a Fourth of July vacation in 2011 with family in Colorado, my wife Melissa Hunter-Noack started having stomach pains. Within a few weeks, she couldn't hold down any food or drink. 

A gastroenterologist diagnosed her with clostridium difficile colitis and prescribed antibiotics for treatment. 

A few weeks later, she noticed some swelling in her ankles and was scheduled for a colonoscopy to check for Crohn's disease.

A CT scan showed an 8 cm mass in her abdomen, and Melissa had exploratory surgery the next morning.

After two hours, Melissa's parents and I still had heard nothing from the doctors, and I knew something was wrong.

Devastating news
Finally, the oncologist came in and confirmed that it was most likely a sarcoma and that Melissa would need a lot of support. The prognosis was poor and the doctor said Melissa would probably not live past a year. 
Seeking a second opinion and another source of hope, we were quickly connected with Shannon Westin, M.D., assistant professor in the Department of Gynecologic Oncology and Reproductive Medicine at MD Anderson.

Dr. Westin immediately made a good impression on the family, and every visit kept a glimmer of hope alive.

Six weeks later, Melissa was diagnosed with a pseudopapillary tumor with epithelioid features. Normally, if the tumor grows within the pancreas, it can be surgically removed. But Melissa's had started on the outside of her uterine wall, which made it rare and without a standard form of treatment

Chemotherapy began in mid-September and Melissa completed one full round. Her abdomen began to swell, and she experienced complications.

Her health was declining rapidly, and her family and I knew that it would be a matter of time.

Cancer spreads

Then, her bowels perforated, and our family was told Melissa had one week if we were lucky.

We were impressed with the level of care that all of the doctors at MD Anderson gave Melissa, and the move to the Andreas Beck Inpatient Palliative Care Unit was no different. The time came for home hospice care, and Melissa passed away at our home on Nov. 3, 2011.

Melissa's legacy

Melissa never lost hope. She always made it a point to include a Bible verse in her daily emails and said she wanted everyone to grow in their faith through her fight with cancer. 

Her way of life and her message through her struggles gave us the strength to spread her voice of helping others. 

Through MD Anderson, my family started the Melissa Hunter-Noack Research Fund for rare/orphan tumors. Our goal is to support the research of rare types of tumors to find treatments for future generations. Her tumor, along with other rare types of cancers, will be studied as long as funding can be provided. 

With help from family and friends, Melissa's twin sister, Kristin, has planned a benefit concert for Oct. 7, at Fitzgerald's in Houston.

All proceeds will go towards her research fund. It will be a night of music  -- one of Melissa's passions -- and headlined by one of her favorite bands - Seryn.

Creating support for others

Her memories have also pushed me, along with a fellow widowed friend to start a support group, www.theyoungandthewidowedhouston.com, for Houston area widows and widowers that are younger than 40.

Our purpose is to find fellowship, support and try to grow through our experiences together.                             

Tuesday, September 18, 2012

Pancreatic Cancer Alliance


Support for people with pancreatic cancer

Living with a serious disease such as pancreatic cancer is not easy. Some people find they need help coping with the emotional and practical aspects of their disease. Support groups can help. In these groups, patients or their family members get together to share what they have learned about coping with their disease and the effects of treatment. Patients may want to talk with a member of their health care team about finding a support group.
People living with pancreatic cancer may worry about the future. They may worry about caring for themselves or their families, keeping their jobs, or continuing daily activities. Concerns about treatments and managing side effects, hospital stays, and medical bills are also common. Doctors, nurses, and other members of the health care team can answer questions about treatment, diet, working, or other matters. Meeting with a social worker, counselor, or member of the clergy can be helpful to those who want to talk about their feelings or discuss their concerns. Often, a social worker can suggest resources for financial aid, transportation, home care, emotional support, or other services.

Online support groups specifically for pancreatic cancer

Cancercare online support group for pancreatic cancer

www.cancercare.org
  • Click on "Find Services by Cancer Type" and choose Pancreatic Cancer for counseling links, free educational programs, booklets and financial assistance.
  • Provides some services in both English and Spanish

The Wellness Community online support group for pancreatic cancer

www.thewellnesscommunity.org
Click on "Join an Online Support Group" and register.
  • Provides some services in both English and Spanish
  • For questions, call local chapter, in Massachusetts:
    The Wellness Community of Greater Boston
    1039 Chestnut Street
    Newton Upper Falls, MA
     (617) 332-1919

Online chat/discussion rooms and email lists specifically for pancreatic cancer

The Pancreatic Cancer Support & Information eCommunity

http://listserv.acor.org/archives/pancreas-onc.html
ACOR.org, the Association of Cancer Online Resources, provides a number of support group email lists. The pancreatic cancer list is a deep resource of information on the challenges of the disease. A true community, caregivers on the list remain to help those newly diagnosed long after their battles have ended.
  • You must subscribe to the list to view the archives or click on "Support and Resources" at the top.

Johns Hopkins Pancreatic Cancer Chat Room

http://www.path.jhu.edu/pancreas/
  • Click on "For Patients and Family" section for the latest information at Johns Hopkins.
  • There is also a Discussion Board on the menu to the left.

Online Chat/Discussion Rooms: General Cancer

Cancercare Online Open Forum

www.cancercare.org
Click on Cancer Care Services, then Support Groups, then Open Forums

Site Hosted by the Association of Cancer Online Resources

www.oncochat.org

Other

For additional information on support services, call the American Cancer Society:  1-800-277-2345

Monday, September 17, 2012

Sunday, September 16, 2012

Bacon, Sausage Linked to Pancreatic Cancer


By Kristina Fiore, Staff Writer, MedPage Today

Processed meats such as sausage, bacon, and cold cuts may increase the risk of pancreatic cancer, but only slightly, researchers found.

For every 50-gram serving of processed meat per day -- a couple of slices of ham, for instance -- relative risk of the disease rose by 19%, Susanna Larsson, PhD, of the Karolinska Institute in Stockholm, and colleagues reported online in the British Journal of Cancer.

Red meat also posed a 29% greater relative risk of pancreatic cancer to men, they found.

"Relative" may be a key word, here, however, since the risk of pancreatic cancer itself is low.
Marji McCullough, ScD, RD, director of nutritional epidemiology for the American Cancer Society, who wasn't involved in the study, emphasized that the overall risks appear to be "modest," although they are "consistent with associations with red and processed meats seen with other other gastrointestinal cancers."
Several studies have shown a link between meat and stomach and colorectal cancers, but it's been unclear as to whether meat also affects pancreatic cancer risk.
So Larsson and colleagues conducted a meta-analysis of 11 studies totaling more than two million patients, 6,643 of whom had pancreatic cancer.
They found that eating at least 120 grams per day of red meat -- determined to be a "standard" serving -- was associated with a 13% increased relative risk of the disease, but it wasn't significant, and there was major heterogeneity between studies (P<0 .001=".001" p="p">
But when those findings were assessed by subgroup, that serving of red meat was associated with an almost 30% increased risk of pancreatic cancer in men (RR 1.29, 95% CI 1.08 to 1.53), and there wasn't significant heterogeneity between studies.
Red meat didn't raise the risk of pancreatic cancer in women, and the researchers said that men generally ate more red meat. That could mean there may be an association between the highest levels of red meat intake and pancreatic cancer risk, they noted.
Processed meat, on the other hand, was associated with a significant increase in pancreatic cancer risk all around. For every daily 50-gram standard serving, relative risk of the disease rose 19% (95% CI 1.04 to 1.36). Again, there wasn't significant heterogeneity between studies.
That increase is likely related to the nitrites and N-nitroso compounds found in processed meats, which have been shown to be carcinogenic and to induce pancreatic cancer in animal models, the researchers wrote.
However, they noted that the association was attenuated and lost significance in a sensitivity analysis that excluded just one of the studies.
Still, McCullough said the findings support American Cancer Society recommendations to limit the intake of red and processed meats to prevent cancer.
"This is more reason to follow a healthy diet, which aside from lowering the risk of cancer, also lowers the risk of heart disease and other diseases as well," she told MedPage Today.
She added that obesity and smoking are already established risk factors for pancreatic cancer.
Larsson and colleagues called for further prospective studies to confirm the findings, which were limited by the individual methodologies of the included studies, the lack of controlling for potential confounders such as weight and diabetes, and challenges in accurately measuring meat consumption.
The study was supported by the Swedish Cancer Foundation.
The researchers reported no conflicts of interest.

Saturday, September 15, 2012

Chase Community Giving



Facebook friends! Make sure you VOTE for us on Chase Community Giving. Let’s make The Lustgarten Foundation one of the TOP charities. The top charities chosen will split a split $2.5 million grant. VOTE TODAY!

https://www.facebook.com/ChaseCommunityGiving?sk=app_162065369655

Friday, September 14, 2012

Nutrition Suggestions from PANCAN


DIET AND NUTRITION
Many people with pancreatic cancer experience significant challenges in the area of diet and nutrition.  With the diagnosis of pancreatic cancer, patients should incorporate a healthy diet and nutritional plan, developed together with a doctor or registered dietitian. 

The patient's nutritional goal should be to consume an adequate amount of fluids, calories, protein and vitamins each day to maintain a desirable weight and activity level.  Small, frequent meals throughout the day (five to six meals/snacks total), with each having a rich source of protein, are usually best tolerated. 

The primary nutrition goals of changes in diet are to:
Prevent or reverse poor nutrition.
Maintain dose and schedule of cancer treatments.
Manage symptoms.
Maintain or improve weight and strength.
Before making changes in diet or using nutritional supplements, it is important to discuss these topics with a doctor or registered dietitian.

The information and services provided by the Pancreatic Cancer Action Network, Inc. are for informational purposes only.  The information and services are not intended to be substitutes for professional medical advice, diagnosis or treatment.  If you are ill, or suspect that you are ill, see a doctor immediately!  The Pancreatic Cancer Action Network does not recommend nor endorse any specific physicians, products or treatments even though they may be mentioned on this site.  080821

Thursday, September 13, 2012

Combining Proton Therapy with the Whipple Procedure: A New Treatment Approach For Pancreatic

As part of a clinical trial combining proton therapy with the whipple procedure, surgeon Carlos Fernandez del Castillo operates on a patient with pancreatic cancer at the Massachusetts General Hospital (MGH).


Join the Denver Walk

Denver, CO
Pancreatic Cancer Research Walk

Sunday, November 4, 2012




Pre-Registration Fee $50
Walk-In Registration Fee $60
Registration 9:00 am
Walk starts at 10:30 am


Join us on Sunday, November 4, 2012 at Sloan's Lake Park, Denver, CO.Pancreatic Cancer Research Events are a great way to increase funding for research and raise awareness for pancreatic cancer. Lustgarten Foundation Events serve as a wonderful celebration of the progress being made in the fight against this disease, and your important participation provides hope for the future.

http://www.kintera.org/faf/home/default.asp?ievent=1024884

Wednesday, September 12, 2012

DIET NUTRITION FOR PANCREATIC CANCER


Responsible for food digestion and blood sugar control, the pancreas is an important part of the body's digestive system. When cancer invades the pancreas, the body often loses its ability to digest foods properly. As a result, pancreatic cancer patients often require a special diet to maintain proper nutrition.



Pancreatic Cancer

Pancreatic cancer affects the body's pancreas, a small organ that plays a large role in digestion. Located deep within the abdomen, the pancreas sits between the stomach and the spine. From this position, the pancreas is able to secrete pancreatic fluid into the small intestine. After its release, pancreatic fluid helps digest foods that have been consumed. In cooperation with the small intestine's digestive juices, the pancreatic fluid breaks down proteins, carbohydrates and fats, along with neutralizing the highly acidic stomach acid. The pancreas also releases hormones that help control blood-sugar levels.



Risks to Nutrition

Because the pancreas is responsible for digesting foods, pancreatic cancer often affects the body's ability to absorb necessary nutrients from food. If nutrient absorption is affected for too long, the body could enter a state of malnutrition. Pancreatic cancer also affects the organ's ability to regulate blood-sugar levels, placing the body at a greater risk for developing diabetes. Additionally, as with many other types of cancer, pancreatic cancer and its associated treatments might cause nausea, decreased appetite, diarrhea and constipation.



Why It Matters

Maintaining proper nutrition while fighting pancreatic cancer is essential for the overall health and well-being of your body. Proper nutrition helps enhance the immune system, improve strength, rebuild body tissues and decrease your risk of developing dangerous infections. Even if you do not feel hungry, it is still important to fuel your body with high-calorie foods throughout the day.



Diet Tips

Before your cancer treatment begins, fill your kitchen with healthy foods. Once treatment starts, you might experience unusual fatigue and weakness, making grocery shopping and meal preparation difficult. If necessary, ask friends and family members to help you prepare meals throughout your treatment. If your appetite does not allow you to eat large meals, aim to eat several small meals throughout the day instead. If you simply cannot manage to eat many solid foods, use liquid meal replacements as a substitute.



Considerations

In severe cases of pancreatic cancer, all or part of the pancreas may need to be removed. As a result, your doctor will likely prescribe a specific diet to help you meet your body's nutritional needs. If your pancreas no longer secrets pancreatic fluids, you may need to take pancreatic enzymes by mouth before meals and snacks. If your body can no longer absorb nutrients from foods, vitamin supplementation may also be necessary.


Article reviewed by RayF Last updated on: Jan 22, 2011


Read more: http://www.livestrong.com/article/363236-diet-nutrition-for-pancreatic-cancer/#ixzz26DxiTzfr

Monday, September 03, 2012

Help us win $10,000 for PANCREATIC CANCER RESEARCH!!!


The celebrity chef sandwich contest is over tonight (Monday) and Chef Michael fell into second place!  We need to get him back in first place by midnight EST.  If Chef Michael wins, The Lustgarten Foundation will be granted $10,000 for research - but we can only win if YOU vote for Chef Michael Ferraro today! Please vote right now and share this message with everyone you know.