Saturday, November 30, 2013
Friday, November 29, 2013
Thursday, November 28, 2013
Why we walk in Denver ...
Thanksgiving will never be the same for Jim and his family. It was his mom's favorite holiday and a day where everyone was welcome in their home. It was also the day they said good-bye.
I walk because ...
Wednesday, November 27, 2013
Colgate University student Brandon Fiegoli studying proteins and potential role in causing cancer
Colgate
students are sharing their experiences conducting research with faculty
members on campus and in the field. This post is by molecular biology
major Brandon Fiegoli, of Bedford, NY.
Every day, you hear about an infamous disease called
cancer. You are constantly reading about celebrities with breast cancer,
kidney cancer, and many more. You may even have friends or family
members fighting the disease. But what do you really know about cancer?
Where does it come from? Why does it occur and how does it harm us?The reason that regulation mechanisms fail to catch mutant cellular division can be due to a number of variables and why these errors occur is not yet fully understood.
In short, cancer is the uncontrolled replication of unhealthy cells that proliferate at a rate faster than the body can destroy them. This growth is regulated and monitored by the cell cycle. A cell’s growth pathway has many points where it can be checked for normal functioning, but it also has gaps in unregulated development where these checkpoint mechanisms can malfunction.
I am working with the protein Kruppel-like factor 4 (KLF4). The protein has been found to directly regulate the cell cycle from going between the G1 phase, a segment when a cell’s internal structures are growing, and S phase, when a cell’s DNA is duplicated. Previous research and scholarship have found that when the protein KLF4 is not present, this checkpoint malfunctions and uncontrolled cellular division occurs.
However, there is more than one pathway that prevents mutant cells from duplicating and becoming malignant. Preliminary findings have shown that KLF4 may potentially have a connection to another protein called mTOR. In separate research, it has been determined that mTOR is known to amplify the growth of tumors, giving mTOR the moniker “Tumor Enhancer.”
My research aims to find a connection between KLF4 and mTOR. Through my initial findings, I have found that cells lacking the KLF4 protein have increased levels of mTOR and, therefore, have an enhanced rate of tumor formation. This semester I will continue to explore the relationship between these proteins.
Cancer will not be beaten by me or my lab alone, but it is research like this that is making strides to understand and beat this terrible disease.
—Brandon Fiegoli ‘14
Tuesday, November 26, 2013
Monday, November 25, 2013
Sunday, November 24, 2013
Denver Woman Battle Pancreatic Cancer
DENVER - November is Pancreatic Cancer Awareness Month, a chance to remind people about one of the deadliest forms of cancer.
Pancreatic cancer is the tenth most commonly diagnosed form of cancer for men and the ninth most commonly diagnosed form of cancer for women. But, for both groups, it is the fourth leading cause of cancer death.
The reason pancreatic cancer is so deadly is it's hard to catch early. In fact, the survival rate for patients after five years is only six percent.
"Pancreas cancer is usually detected at a late stage in most patients," explained Dr. Colin Weekes, the Director of the Medical Oncology Pancreas Program at University of Colorado Hospital. "That really is a function of where the pancreas lies in the body. So, unfortunately patients can develop tumors without developing any symptoms. And that allows the tumor to grow for some period of time before you actually get clinically pancreatic cancer-type symptoms."
Those symptoms first showed up for Jennifer Nuanes as abdominal pain. The pain was so intense, Nuanes' doctor sent her straight to the hospital. Within days, the former parole officer was diagnosed with stage one pancreatic cancer.
Surgeons removed Nuanes' spleen and most of her pancreas in Sept. 2012. At the time, they were optimistic they could cure her. But 10 months later, the pain returned, and so had Nuane's cancer. This time it was stage four.
"When we got stage four, it was devastating again. We didn't think it would ever come back and that's when we really leaned on our support," Nuanes said.
For Nuanes, the team leader of that support system is her partner, Celina.
"It's absolutely amazing," Nuanes said. "She became a doctor, a nutritionist, a nurse, you name it. She's researching absolutely everything so that we can continue to battle this."
Dr. Weekes says it's important for patients to maintain that same attitude and not to give up.
"There's a fair number of patients out there who have curable pancreas cancer but are told that they have a really bad disease and just sort of forget about therapy," Weekes said.
At University of Colorado's clinic, that therapy includes a multi-disciplinary clinic. The patients are evaluated by a team of doctors, who decide on the best plan for treatment. Dr. Weekes says his clinic has seen about 200 patients over the last year, and after reviewing those patients, they changed the treatment plan for about one-third of them.
Treatment for Nuanes includes chemotherapy right now. But, she says doctors have given her six to twelve months. And while it's difficult, she says she's still not defeated.
"You have to just endure the pain. I don't want to paint the picture that things are easy because they're really not," Nuanes said. "There's days when you can't get out of bed. There's days you can't eat. But, the support and the love around you is really what gets you through it."
Learn more at: http://www.9news.com/news/local/article/364961/222/Denver-woman-battles-pancreatic-cancer-
Pancreatic cancer is the tenth most commonly diagnosed form of cancer for men and the ninth most commonly diagnosed form of cancer for women. But, for both groups, it is the fourth leading cause of cancer death.
The reason pancreatic cancer is so deadly is it's hard to catch early. In fact, the survival rate for patients after five years is only six percent.
"Pancreas cancer is usually detected at a late stage in most patients," explained Dr. Colin Weekes, the Director of the Medical Oncology Pancreas Program at University of Colorado Hospital. "That really is a function of where the pancreas lies in the body. So, unfortunately patients can develop tumors without developing any symptoms. And that allows the tumor to grow for some period of time before you actually get clinically pancreatic cancer-type symptoms."
Those symptoms first showed up for Jennifer Nuanes as abdominal pain. The pain was so intense, Nuanes' doctor sent her straight to the hospital. Within days, the former parole officer was diagnosed with stage one pancreatic cancer.
Surgeons removed Nuanes' spleen and most of her pancreas in Sept. 2012. At the time, they were optimistic they could cure her. But 10 months later, the pain returned, and so had Nuane's cancer. This time it was stage four.
"When we got stage four, it was devastating again. We didn't think it would ever come back and that's when we really leaned on our support," Nuanes said.
For Nuanes, the team leader of that support system is her partner, Celina.
"It's absolutely amazing," Nuanes said. "She became a doctor, a nutritionist, a nurse, you name it. She's researching absolutely everything so that we can continue to battle this."
Dr. Weekes says it's important for patients to maintain that same attitude and not to give up.
"There's a fair number of patients out there who have curable pancreas cancer but are told that they have a really bad disease and just sort of forget about therapy," Weekes said.
At University of Colorado's clinic, that therapy includes a multi-disciplinary clinic. The patients are evaluated by a team of doctors, who decide on the best plan for treatment. Dr. Weekes says his clinic has seen about 200 patients over the last year, and after reviewing those patients, they changed the treatment plan for about one-third of them.
Treatment for Nuanes includes chemotherapy right now. But, she says doctors have given her six to twelve months. And while it's difficult, she says she's still not defeated.
"You have to just endure the pain. I don't want to paint the picture that things are easy because they're really not," Nuanes said. "There's days when you can't get out of bed. There's days you can't eat. But, the support and the love around you is really what gets you through it."
Learn more at: http://www.9news.com/news/local/article/364961/222/Denver-woman-battles-pancreatic-cancer-
Friday, November 22, 2013
Pancreatic Cancer in the News
| Remembering Sarah Henry's short fight with pancreatic cancer KPLC-TV
Pancreatic cancer
has the highest mortality rate of all cancers, leaving those diagnosed
with little hope of a bright future. The disease took the life of
34-year-old ...
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| Photos: PurpleStride in Parsippany strives to stop pancreatic cancer NorthJersey.com
Parsippany
turned purple on Sunday, Nov. 10, a windy but sunny day when more than
2,000 people turned up at the Mack-Cali Corporate Complex for ...
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| Nut consumption linked to lower pancreatic cancer risk in women NutraIngredients.com
Frequent consumption of nuts may be associated with a lower risk of developing pancreatic cancer in woman, according to new findings.
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| This November Dr. Michael Colleran Promotes the Connection ... DigitalJournal.com
November is Pancreatic Cancer Awareness Month and San Luis Obispo dentist Dr. Michael Colleran and his staff are promoting an increased awareness ...
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| Vatican Honors Md. Teen For Breakthrough Pancreatic Cancer ... CBS Local
Andraka developed a simple test that detects early stage pancreatic cancer in mice. ... working with two bio-tech firms to develop his test for pancreatic cancer.
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| Cavalier 5K run/walk Saturday to benefit woman with pancreatic ... Salisbury Post
Now, she is battling pancreatic cancer and her medical bills are mounting. The event Saturday, Nov. 23, is the brainchild of Debbie Sousa, health science ...
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| East Lancashire GP Michael Barsby loses battle with pancreatic ... Lancashire Telegraph
He and his wife Susan had recently taken part in a charity calendar with members of Crossfit Clitheroe to raise money for Pancreatic Cancer UK.
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| Local family forever changed by pancreatic cancer Port Lavaca Wave
Pancreatic cancer is a disease Calhoun High School teacher Megan Strauss, 39, of Port Lavaca, knows well. Strauss lost her father, Dan Yanta, to pancreatic ...
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| Nuvilex's Acquisition of Diabetes Rights Should Put the Company on ... Wall Street Journal
While the company's future Phase 3 clinical trials in pancreatic cancer should bring lots of attention to Nuvilex, particularly if they produce a treatment that beats ...
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| PSC chairman Gallagher: cancer battle is "fight of my life" KXLH Helena News
HELENA - It's been nearly five months since Montana Public Service Commission chairman Bill Gallagher, 54, was diagnosed with pancreatic cancer. Gallagher ...
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| Blogs | 3 new results for pancreatic cancer |
| Naughty Dog replica craftsman crowdfunds support in fight against ... S. Prell
David
Vigil is a leathersmith and owner of That Vigilante, where he sells
replicas of gear seen in Naughty Dog games. Nathan Drake's belt buckle,
holster and ...
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| Pancreatic Cancer Awareness proclamation | Ellwood City News EllwoodCity.org Staff
On Wednesday, November 06, 2013 Mayor Anthony J. Court was honored to proclaim November 2013 as “Pancreatic Cancer Awareness Month” in the Borough ...
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| Tree nut consumption lowers pancreatic cancer risk - Research ... Carolanne Wright
If
you need another excuse to enjoy a handful of your favorite tree nut,
new research suggests consumption of nuts can slash the risk of
developing pancreatic ...
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Thursday, November 21, 2013
Pancreatic Cancer in the News
| Denver woman battles pancreatic cancer 9NEWS.com
DENVER - November is Pancreatic Cancer Awareness Month, a chance to remind ... Pancreatic cancer is the tenth most commonly diagnosed form of cancer for ...
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| Naughty Dog replica craftsman crowdfunds support in fight against ... Joystiq
David
Vigil is a leathersmith and owner of That Vigilante, where he sells
replicas of gear seen in Naughty Dog games. Nathan Drake's belt buckle,
holster and ...
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| Fashion, food help raise money to fight pancreatic cancer: Slideshow The Business Journal of Milwaukee (blog)
Milwaukee-area business executives gathered at a 5th Ward warehouse Saturday afternoon to see a fashion show and raise money to fight pancreatic cancer.
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| Facing cancer battle, DiGenova stays positive ThisWeekNews
In July, DiGenova, 68, was diagnosed with pancreatic cancer, and in August, the longest-serving council member in Delaware's history had surgery for a ...
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| Schoolboy's charity drive in memory of tragic dad Birmingham Mail
Ten-year-old Jack Cooper, from Hollywood, lost his beloved dad James to pancreatic cancer in July, just nine months after he was diagnosed by specialists at ...
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| Sexual abuse victim welcomed cancer diagnosis, hearing told Sydney Morning Herald
"A doctor examined me a few years ago and said 'Ive got some bad news for you - you've got pancreatic cancer, how do you feel?' "What I didn't say was what I ...
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| Women's Study Suggests Eating Tree Nuts Reduces Pancreatic ... Business Wire (press release)
This is the first study to measure the association between pancreatic cancer risk and nut consumption. Pistachios were among the tree nuts included in the study.
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| Tributes to doctor who died aged 43 Burnley Express
Dr Barsby died on Friday after a battle with pancreatic cancer, aged only 43. The father-of-three who lived in Clitheroe, but worked as a GP at Kiddrow Lane ...
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| Role of gene in breast cancer Bangalore Mirror
Some studies show that mutations in the BRCA1 gene increases a women's risk of uterine, colonic and pancreatic cancer as well. BRCA 2 mutations increase ...
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| Nov 18, 2013 Murray Ledger and Times
November is Pancreatic Cancer Awareness Month. The Buck CANCER Relay for Life Team will have a rebate day at The Big Apple Café on Wednesday, Nov.
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Tuesday, November 19, 2013
Monday, November 18, 2013
Thursday, November 14, 2013
Why I Fight: Kim Honors Her Dad Rich
November 3 will be both an uplifting yet bittersweet day for me and my family. It marks the anniversary of my father Rich’s diagnosis of pancreatic cancer before he died from the disease eleven months later in October 2005. This year, November 3 also marks the day more than 500 participants of all ages from across the Rocky Mountain region will join together in the spirit of hope for our Denver Pancreatic Cancer Research Walk to benefit The Lustgarten Foundation.
I never would have imagined spending countless hours all year working with more than 100 volunteers to produce an event of this size. However, winning the fight against this disease and supporting the Foundation’s mission to find a cure is our inspiration.
My father Rich was a man who loved life and when you were with him, you loved life too. He was a joyful person who enjoyed the outdoors, and treasured his family and friends. He was my mentor and hero. He was also a fighter.
Our family was devastated by his diagnosis and death but we were also determined to keep hope alive. While on a trip, my mother Meg, my sister Kara and I were inspired by a charity event and for the first time thought, why not do this back home? We decided to partner with The Lustgarten Foundation because we were attracted by their dedication to find an early detection test and a cure for this dreadful disease. Also, every single donation goes directly to advancing pancreatic cancer research.
Today, the walk our dad inspired gives hundreds of other families a way to cope with the loss of a loved one and hope to those living with pancreatic cancer. He would be so proud.
Since we launched the walk seven years ago, we have been deeply moved by the love, support and encouragement of so many others impacted by this disease. Our numbers are growing and so is our will to win. Together we can make a difference.
Click here to read more.
Wednesday, November 13, 2013
Congratulations Denver!
While Lustgarten is still counting, it looks like the Denver walk on November 3, 2013 raised close to $110,000 and all those dollars are going straight into research!
Thank you to all the Coloradans who are committed to finding a cure. We couldn't do it without you!!
We'll start posting pictures soon! So visit this blog often!
Tuesday, November 12, 2013
Pancreatic Cancer in the News!
| Pancreatic Cancer Awareness Month KARK
LITTLE ROCK, AR -- November is Pancreatic Cancer Awareness Month and the PANCAN local volunteer group is diligently working to create hope through ...
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| Cupcake queens raise funds for pancreatic cancer research St George and Sutherland Shire Leader
Cupcake queens raise funds for pancreatic cancer research ... the recent Garage Sale Trail raised $187 for the Australian Pancreatic Cancer Genome Initiative.
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| New hope for blood test to catch pancreatic cancer early MTBeurope
A simple blood test to detect gene fragments unique to pancreatic cancer cells could be on the horizon following promising results in a small preliminary study at ...
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| Bake and share in St Ives for pancreatic cancer Cambridge News
Angela Parker, from the firm, is holding the event in pancreatic cancer awareness month as a tribute to her father-in-law local businessman Barry Parker who ...
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| Cupcake queens raise funds for pancreatic cancer research St George and Sutherland Shire Leader
A
cake stall held by Jodie Tardelli (right), of Peakhurst, and her friend
Amanda Jachowski, during the recent Garage Sale Trail raised $187 for
the Australian ...
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| Didn't think about cancer until daughter diagnosed Seacoastonline.com
According to information provided by the Pancreatic Cancer Action Network, www.pancan.org, the top five cancer killers are currently lung, colorectal, breast, ...
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| Can our immune system fight against pancreatic cancer? Telemanagement
(TeleManagement) A group of researchers led by the University of Pennsylvania's Perelman School of Medicine and Abramson Cancer Center, in collaboration ...
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| Former UFO Bassist PETE WAY Diagnosed With Prostate Cancer BLABBERMOUTH.NET
This is prostate cancer. It's not lung cancer. It's not pancreatic cancer. If you're going to get cancer, this is the best one you can have — and they caught it early.".
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| Women's Rowing Honor Valarie Altimari at Purple Stride ... Temple University Athletics
PHILADELPHIA- Temple women's rowing spent their Saturday, November 9th, off the water at the Purple Stride 5k for Pancreatic Cancer at Memorial Hall, ...
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| Ian Laperriere Joins The Pancreatic Cancer Action Network And ... EIN News (press release)
PHILADELPHIA,
Nov. 5, 2013 /PRNewswire/ -- More than 4,500 people will run and walk a
5K course to raise funds and awareness about pancreatic cancer, the ...
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| Blogs | 1 new result for pancreatic cancer |
| More than 1,500 Expected at Pancreatic Cancer Action Network 5K ... The Alternative Press
WEST ORANGE, NJ - Pancreatic cancer is the fourth leading cause of cancer death in the United States, and over 1500 people are expected to participate in the ...
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Monday, November 11, 2013
Monday, November 04, 2013
Sunday, November 03, 2013
Saturday, November 02, 2013
2013 Denver Lustgarten Pancreatic Research Walk Silent Auction Items
This is just a sampling of the awesome
auction items we'll have available tomorrow before the 2013 Lustgarten Pancreatic Cancer Research Walk. In
addition to these great gift cards, there are wine baskets, amazing
experience, collectibles, autographed sports attire, and so much more
... come join us and help us fight for a cure to pancreatic cancer!!
The walk starts tomorrow at 10:30am. Registration opens at 9am.
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